We describe RosettaRemodel, a generalized Synthetic Swiss Lace Part Wig framework for flexible protein design that provides a versatile and convenient interface to the Rosetta modeling suite.RosettaRemodel employs a unified interface, called a blueprint, which allows detailed control over many aspects of flexible backbone protein design calculation

Abstract Background Mutations that impair mitochondrial functioning are associated with a variety of metabolic and age-related disorders.A barrier to rigorous tests of the role of mitochondrial dysfunction in aging processes has been the lack of model systems with relevant, naturally occurring mitochondrial genetic variation.Toward the goal of deve

Synthetic Swiss Lace Part Wig The actions of fibroblast growth factors (FGFs), particularly the basic form (bFGF), have been described in a large number of cells and include mitogenicity, angiogenicity and wound repair.The present review discusses the presence of the bFGF protein and messenger RNA as well as the presence of the FGF receptor messeng

Abstract Background Falls are a global public problem and may be an important cause of death in older adults.However, older adults with mild cognitive impairment(MCI) are more likely to fall and suffer more damage than older adults with normal cognitive function, which shows the importance of preventing falls.More and more evidence shows that Badua